Phytochemical screening and potential of antimicrobial and Anti-inflammatory activity of organic extract derived from Tragia plukenetii Radcl. Sm

Abstract

Plants and other natural sources are the only remedial agents to cure the health illness and health maintenance up to the development of modern technology. Later, the Technological advancement creates a lot to protect ourselves using synthetic drugs from the various human health complications with some side effects. In addition, the evolution of new pathogenic bacterial strains has developed a resistance against regularly used antibiotics is a prime anxiety for global health community. Such side effects are needed to be nullified, hence, it is necessary to discover new biologically active drugs to treat and inhibit the pathogenic organisms. Therefore, the usage of medicinal plants is the better remedial source to overcome these problems. With this concern, We have used the medicinal plant Tragia plukenetii Radcl.Sandm in this study and this plant extract was collected using Water, Petroleum ether, Ethanol and Methanol. As a result, Carbohydrates, Proteins, Amino acids, Flavonoids were found more while; Terpenoids were absent in all the extract except Water. Moreover, Alkaloids and Tannins were present in all the solvent extract. In vitro antibacterial potential against different human bacterial pathogens, haemolysis and anti-inflammatory properties were tested for all the solvent extracts. The highest antibacterial and anti-inflammatory activity were found in the Water extracts against all the tested organisms when compared to other solvents such as Methanol, Ethanol, and Petroleum Ether extracts. This finding supports the plant T. plukenetii could be potentially used as a nutraceutical for antibacterial and anti-inflammatory properties.